Monday, April 11, 2011
PNA Peptide Nucleic Acid
The gateway to information on peptide nucleic acids. PNA or peptide nucleic acid is a DNA mimic with a pseudopeptide backbone. PNA is an extremely good structural mimic of DNA (or RNA).
Peptide nucleic acids (PNA) are DNA mimics with a pseudopeptide backbone. PNA is an extremely good structural mimic of DNA (or RNA), and PNA oligomers are able to form very stable duplex structures with Watson-Crick complementary DNA, RNA (or PNA) oligomers, and they can also bind to targets in duplex DNA by helix invasion. Therefore, these molecules are of interest in many areas of chemistry, biology, and medicine including drug discovery, genetic diagnostics, molecular recognition and the origin of life.
A nucleic acid is a macromolecule composed of chains of monomeric nucleotides. In biochemistry these molecules carry genetic information or form structures within cells. The most common nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). Nucleic acids are universal in living things, as they are found in all cells and viruses. Nucleic acid was first discovered by Friedrich Miescher.
Ribonucleic acid, or RNA, is a nucleic acid polymer consisting of nucleotide monomers, which plays several important roles in the processes of translating genetic information from deoxyribonucleic acid (DNA) into proteins. RNA acts as a messenger between DNA and the protein synthesis complexes known as ribosomes, forms vital portions of ribosomes, and serves as an essential carrier molecule for amino acids to be used in protein synthesis.