The NIPSNAP proteins comprise a family of evolutionarily well-conserved proteins with strong sequence similarity to the central portion of a protein encoded by C. elegans chromosome III between a 4-nitrophenylphosphatase (NIP) domain and non-neuronal SNAP25-like protein. NIPSNAP2, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR in approximately 40% of glioblastomas, the most common and malignant form of central nervous system tumors. It is widely expressed and most abundant in heart and skeletal muscle. NIPSNAP proteins have been suggested to be important in vesicular transport. NIPSNAP2 antibody is predicted to not cross-react with any other members of the NIPSNAP protein family.
Additional Names : NIPSNAP2 (IN), Non-neuronal SNAP25-like protein 2, Glioblastoma-amplified sequence, GBAS
Left: Western blot analysis of NIPSNAP2 in human skeletal muscle tissue lysate with NIPSNAP2 antibody at (A) 1 and (B) 2 µg/ml.
Below:Immunohistochemistry of NIPSNAP2 in mouse skeletal muscle tissue with NIPSNAP2 antibody at 2.5 µg/ml.
Other Product Images
Source :NIPSNAP2 antibody was raised against a 14 amino acid peptide near the center of human NIPSNAP2.
Purification : Affinity chromatography purified via peptide column
Clonality and Clone : This is a polyclonal antibody.
Host : NIPSNAP2 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application : NIPSNAP2 antibody can be used for detection of NIPSNAP2 by Western blot at 1 – 2 µg/ml.
Tested Application(s) : E, WB, IHC
Buffer : Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide :Cat.No. 4953P - NIPSNAP2 Peptide
Long-Term Storage : NIPSNAP2 antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control :
1. Cat. No. 1375 - Human Skeletal Muscle Tissue Lysate
Species Reactivity : H, M, R
GI Number : 17380133
Accession Number : O75323
Short Description : (IN) Non-neuronal SNAP25-like protein 2
1. Seroussi E, Pan HQ, Kedra D, et al. Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family. Gene 1998; 212:13-20.
2. Wang X-Y, Smith DI, Liu W, et al. GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR. Genomics 1998; 49:448-51.