Wednesday, February 2, 2011

Peptide Microarray

Bio-Synthesis not only synthesizes peptides but also provide peptide microarray by using high-precision printing technology, the peptides or proteins can be spotted on membrane-coated glass slides. Using different detection technologies, recombinant proteins/antibodies, cell lysate or serum samples can be quantitatively assayed. It has wide applications in protein-protein interaction studies, including antigen-antibody recognitions, kinase-substrate bindings, pathway analysis, biomarker screenings, and much more.

A DNA microarray is a high-throughput technology used in molecular biology and in medicine. It consists of an arrayed series of thousands of microscopic spots of DNA oligonucleotides, called features, each containing picomoles of a specific DNA sequence. This can be a short section of a gene or other DNA element that are used as probes to hybridize a cDNA or cRNA sample (called target) under high-stringency conditions.

A protein microarray, sometimes referred to as a protein binding microarray, is a piece of glass on which different molecules of protein have been affixed at separate locations in an ordered manner thus forming a microscopic array. These are used to identify protein-protein interactions, to identify the substrates of protein kinases, or to identify the targets of biologically active small molecules.

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