Friday, February 4, 2011

DNA Chimerism


Bio-Synthesis offer various type of oligonucleotide chimeric synthesis. If you require multi-milligram quantities of purified oligos with mixed bases of RNA, DNA, O-methyl RNA, Constrained Nucleotide, PNA or peptide hybid synthesis, then the Bio-Synthesis is your company of choice. The chimeric oligos can also be synthesized with the full regular phoshodiester bonds or partially substituted with phosphorothioate linkages.

Chimerism DNA

In zoology, a chimera is an animal that has two or more different populations of genetically distinct cells that originated in different zygotes; if the different cells emerged from the same zygote, it is called a mosaicism. Chimerism is rare in human beings: there have been only about 40 reported cases.

DNA Polymerases

DNA polymerases are a family of enzymes critical for all forms of DNA replication. DNA polymerase synthesizes a new strand of DNA by extending the 3' end of an existing nucleotide chain, adding new nucleotides matched to the template strand one at a time.

Microchimerism

Microchimerism is the presence of a small number of cells, genetically distinct from those of the host individual. The most common form is fetomaternal microchimerism (or fetal chimerism) whereby cells from a fetus pass through into the mother. Fetal cells have been documented to persist in maternal circulation for as long as 38 years. Microchimerism had also been shown to exist after blood transfusions to a severely immunocompromised population of patients who suffered trauma.

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